Finding Answers to the Most Challenging Questions in Genomics

Generating research-grade data from even the most difficult samples with documented QC and predictable delivery
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Finding Answers to the Most Challenging Questions in Genomics

Generating research grade data from even the most difficult samples with documented QC and predictable delivery

Services

Short Read Sequencing

Whole genome, exome, and targeted DNA sequencing.

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Bulk RNA-Seq

Bulk and targeted RNA profiling.

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Long Read Sequencing

PacBio and Nanopore long reads.

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Single Cell

Single cell and single nucleus profiling.

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Spatial Transcriptomics

Spatial RNA profiling in tissue.

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High-Plex Proteomics

Somamer and PEA based proteomics.

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High-Throughput qPCR

Standard BioTools integrated fluidic circuits.

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Infinium Arrays

Genotyping and methylation arrays.

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Clinical Trials Supported with Research Grade Data

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End-to-end Quality Control

From study design through delivery, each stage is defined by a robust QC process.

1

Study design

Assay, depth and QC set up front.
2

Sample intake QC

Identity, quantity and integrity confirmed.
3

Lab workflow QC

Extraction, library and runs checked.
4

Run review

Run metrics checked against spec.
5

Results ready

Data and metadata ready for analysis.

Built for difficult and degraded samples

GTAC@MGI maintains performance across the full spectrum of sample quality, from higher quality material to heavily degraded and limited samples.

Sample quality range different providers can support
GTAC@MGI maintains performance across the full sample quality range, including low quality and degraded samples. Traditional CRO support is shown as more limited.
Publication example
A phase II study of palbociclib plus letrozole plus trastuzumab as neoadjuvant treatment for clinical stages II and III ER+ HER2+ breast cancer (PALTAN)
GTAC@MGI performed the genomic analysis. RNA sequencing was conducted on tumor-rich biopsy samples from 16 of the 26 patients enrolled, reflecting limited RNA seq availability due to sample quality and tumor content.
Publication example
Veliparib in Combination With Platinum Based Chemotherapy for Advanced Squamous Cell Lung Cancer A Randomized, Multicenter Phase III Study
RNA seq was performed on archived FFPE tumor samples, material that is notoriously degraded and difficult to process. GTAC@MGI generated the transcriptomic data, enabling biomarker driven subgroup analysis in one of the largest trials conducted in this patient population.
Built for difficult and degraded samples

GTAC@MGI maintains performance across the full spectrum of sample quality, from higher quality material to heavily degraded and limited samples.

Publication example
A phase II study of palbociclib plus letrozole plus trastuzumab as neoadjuvant treatment for clinical stages II and III ER+ HER2+ breast cancer (PALTAN)
GTAC@MGI performed the genomic analysis. RNA sequencing was conducted on tumor-rich biopsy samples from 16 of the 26 patients enrolled, reflecting limited RNA-seq availability due to sample quality and tumor content.
Publication example
Veliparib in Combination With Platinum-Based Chemotherapy for Advanced Squamous Cell Lung Cancer: A Randomized, Multicenter Phase III Study
RNA-seq was performed on archived FFPE tumor samples, material that is notoriously degraded and difficult to process. GTAC@MGI generated the transcriptomic data, enabling biomarker-driven subgroup analysis in this large clinical trial.

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